Immunopathogenesis of Juvenile Systemic Sclerosis
نویسندگان
چکیده
منابع مشابه
[Juvenile Systemic Sclerosis].
mento cutâneo, evoluindo para áreas de despigmentação cutânea em ‘sal e pimenta’ (Fig. 1), e aparecimento de úlceras digitais (Fig. 2). Actualmente medicada com metotrexato subcutâneo, metilprednisolona e bosentan. A ESJ tem uma incidência de 0,27 casos por milhão de crianças1 e apresenta particularidades que a distinguem das formas adultas de esclerose sistémica.2 A abordagem terapêutica em id...
متن کاملCurrent perspectives on the immunopathogenesis of systemic sclerosis
Systemic sclerosis (SSc or scleroderma) is a progressive and highly debilitating autoimmune disorder characterized by inflammation, vasculopathy, and extensive fibrosis. SSc is highly heterogeneous in its clinical presentation, extent and severity of skin and internal organ involvement, and clinical course and has the highest fatality rate among connective tissue diseases. While clinical outcom...
متن کاملJuvenile systemic sclerosis: review of 15 patients
Results Results: Fifteen patients were identified and included in the analysis, 3 of them were overlap syndromes. Eleven girls (73%), 13 (87%) Caucasians, with a mean age at diagnosis of 11.1±3.0 (3–15) years and a mean disease duration of 7.2±4.2 years (8 months-17 years). In 14 (93%) cases, the first symptom attributable to JSSc was Raynaud’s phenomenon, followed by arthritis and/or puffy han...
متن کاملFactors affecting survival in juvenile systemic sclerosis.
OBJECTIVES To determine whether demographic, clinical and immunological features may predict the outcome in juvenile SSc (JSSc). METHODS Clinical and laboratory characteristics of patients with JSSc collected from paediatric rheumatology centres worldwide were analysed. First, univariate tests identified those features significantly related with fatal outcome, and then multivariate logistic r...
متن کاملThe immunopathogenesis of multiple sclerosis.
Multiple sclerosis (MS) is a T cell-mediated autoimmune disease that is triggered by unknown exogenous agents in subjects with a specific genetic background. Genes of the major histocompatibility complex class II region are the only ones that have been consistently associated with the disease. However, susceptibility is probably mediated by a heterogeneous array of genes, which demonstrate epis...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2019
ISSN: 1664-3224
DOI: 10.3389/fimmu.2019.01352